The Monarch has taped a first-hand account about his experience with cancer, set to air as part of this year's Stand Up To Cancer campaign, run by a leading cancer charity and a television broadcaster.
Buckingham Palace stated the King would reflect on his "healing process" as a person living with the disease, in a televised statement on Friday at the evening slot.
The recording, filmed within a royal residence recently, will emphasise the critical nature of preventative health checks to ensure more people detect the condition at an treatable phase.
This represents a infrequent public commentary on the health of the King, who has been receiving ongoing care since his condition was announced in early last year. Analysts suggest unlikely the King will specify his type of cancer.
The awareness initiative each year raises funds for clinical trials and treatment and encourages people to get check-ups to boost the probability of an timely detection.
The King's public discussion about his health challenge, and managing the disease, has been intended to increase understanding and to encourage more people to get checked - and this will be taken a step further with this unique royal involvement.
Up until now the King's primary strategy to his cancer has been to maintain his duties, maintaining a full diary alongside his ongoing course of treatment, and he is understood not to have sought to be defined by his diagnosis.
Recently has seen the King, 77, embarking on several foreign visits, notably to Italy and Canada, and receiving the biggest number of inward state visits to the UK for almost 40 years, which included the German president in recent days.
The upcoming Stand Up to Cancer broadcast on the network, hosted by presenters such as several TV personalities, will appeal to people not to be scared of getting health screenings.
All three have been had experience with cancer - Davina McCall revealed last month she had undergone surgery for a tumour, while another presenter was treated for thyroid cancer over a decade ago. Presenter Adam Hills has previously discussed his parent, who had one form of cancer and then later leukaemia.
The programme will target the approximate nine million people in the UK who Cancer Research UK estimate are not up to date with national health programmes, with an digital tool to let people see if they are eligible for screenings for key health indicators.
In an bid to clarify health tests and demonstrate the value of early diagnosis there will be a direct feed from cancer clinics at Addenbrooke's and Royal Papworth hospitals in Cambridge.
"I want to take the fear surrounding preventative tests and show all people that they are not isolated in this," commented a presenter.
Right now in the UK, there are a number of national health screening services - for specific cancers - accessible for certain age groups.
A emerging scheme for lung health is also being phased in for people at increased risk of developing the illness, primarily aimed at people in a specific age bracket, who currently smoke or were former smokers.
Individuals may discuss specific tests, but there is not a universal scheme operational.
The charity project, which has collected £113m over the past decade, is funding 73 research studies involving 13,000 patients.
The Monarch, in a statement for dignitaries at a gathering for cancer charities in earlier this year, had discussed acknowledging the "overwhelming and at times alarming situation" for patients and their support networks.
But he noted his first-hand encounter of living with cancer had revealed that "the darkest moments of disease can be illuminated by the kindness of others," as he commended those who supported individuals with the illness.
The Palace has not revealed the nature of cancer the King has, or what treatment he has been given. The King's cancer was detected subsequent to he had undergone a prostate procedure.
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